Biological markers of intellectual disability in tuberous sclerosis
نویسندگان
چکیده
منابع مشابه
Biological markers of intellectual disability in tuberous sclerosis.
BACKGROUND Intellectual disability (ID) is highly prevalent in tuberous sclerosis (TS). Putative neurobiological risk factors include indices of cortical tuber (CT) load and epilepsy. We have used univariate and multivariate analyses, including both CT and epilepsy measures as predictors, in an attempt to clarify the pattern of cross-sectional associations between these variables and ID in TS. ...
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One hallmark of tuberous sclerosis (TSC) is the presence of highly epileptogenic dysplastic cerebral cortex (tubers) composed of abnormally shaped neurons and giant cells. Mutation of the TSC gene (TSC2) may disrupt differentiation and maturation of neuronal precursors, since the TSC2 gene product tuberin is believed to regulate cellular proliferation. To test the hypothesis that cells in tuber...
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ژورنال
عنوان ژورنال: Psychological Medicine
سال: 2007
ISSN: 0033-2917,1469-8978
DOI: 10.1017/s0033291707000177